Tottenham Hotspur dealt two significant injury blows ahead of Aston Villa Premier League clash

Tottenham Hotspur captain Hugo Lloris has been ruled out for the remainder of the Premier League season after picking up a muscle problem.

The injury was sustained during Spurs' 6-1 humiliation at Newcastle United last month, with interim head coach Ryan Mason confirming the 36-year-old's season is over.

As part of a double setback, left-back Ryan Sessesgon will also not play again this season. The 22-year-old has been out since February due to a hamstring issue which he sustained in Spurs' win over Man City.

It means neither player will play a part against Aston Villa next weekend, with Unai Emery's side three points behind the North London club in the race for European football.

"Both sustained big injuries,” said Mason.

“Hugo’s one got confirmed so he’s out for the rest of the season unfortunately and then Ryan as well – we’ve got a couple of others who hopefully aren’t too far away from being back and helping the group but that’s just a day-to-day one and we’ll assess them each day.”

Mason added: “Hugo is out for the season, we had the results back and it’s obviously disappointing. We kind of feared that initially, we did some more tests and he won’t play again for us this season. Ryan had a significant injury, he’s been out for a long time, and Ryan won’t feature for the rest of the season.”

Spurs moved three points ahead of Villa on Saturday afternoon as they won 1-0 against Crystal Palace as Wolves handed Emery's side a 1-0 loss.

Rodrigo Bentancur is likely to remain sidelined against Villa as he continues to recover from an anterior cruciate ligament injury.

Mason added: "With these types of injuries, you need to be very careful. We see sometimes that they can reoccur, and we're assessing him day by day. He's making progress, but at the moment, it's probably too early to set a return date."